Rocuronium Effective Dose for Laparoscopic Cholecystectomy

Brasilia University Hospital

Status and phase: Completed; Phase 3

Conditions: Muscle Relaxation

Treatments: Drug: rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT03043157

CAAE 60322116.2.0000.0025

Details and patient eligibility

About

This is an adaptative study where each participant's rocuronium dose will depend on the previous patient's response, being higher if it was not enough and lower if it was more than enough.

Full description

Rocuronium is one of the most used neuromuscular blockers to help intubation and to relax abdominal wall for laparoscopic surgery.

Rocuronium intubation dose can be enough for intubation but not last enough for excellent laparoscopic conditions. There is little variation in time from anesthesia induction to the end of the laparoscopy for cholecystectomy and avoiding excess rocuronium dose can help providing excellent conditions and fast track extubation.

Dixon's up-and-down method will guide this dose-finding study for the ED50.

Enrollment: 30 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• general anesthesia

Exclusion criteria

• deny participation

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Dose-finding group

Other group

Description:

The first patient will receive rocuronium 0,6mg/kg. After that, every patient's dose will depend on the outcome of the previous patient. It will go up 0,1mg/kg if the laparoscopic conditions were not excellent or go down 0,1mg/kg otherwise.

Treatment:

Drug: rocuronium