Role of Adipokines in Glucose Regulation During Pregnancy and in Fetal Development (GEN3G)

U

Université de Sherbrooke

Status

Unknown

Conditions

Gestational Diabetes
Insulin Resistance

Study type

Observational

Funder types

Other

Identifiers

NCT01623934
GEN3G

Details and patient eligibility

About

This study includes 2 phases. During phase 1, pregnant women are followed over the course of pregnancy. The phase 2 is a follow-up of the mother-child dyad at 3 and 5 year after delivery. The purpose of this phase 1 is to : assess the contribution and interactions of adipokines in the development of insulin resistance during pregnancy and gestational diabetes; assess levels of maternal adipokines as determinants of development and fetal growth; determine the genetic variations that influence levels of adipokines and glucose regulation during pregnancy and in newborns. The purpose of this phase 2 is to: identify DNA methylation variations at birth that are predictive of childhood overweight/obesity. identify maternal characteristics associated with DNA methylation variations predictive of childhood overweight/obesity. establish whether the loci predictive of childhood overweight/obesity at birth are still differentially methylated at 5 years of age (samples collected at 5 years of age). identify DNA methylation variations at birth that are predictive of childhood neurodevelopment problems at 3 and 5 years of age.

Enrollment

1,086 patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age ≥ 18 yrs
  • gestational age between 6 and 13 weeks from last menstrual period
  • no recognized diabetes or drugs interfering with glucose metabolism
  • alcohol < 2 drinks/day
  • not involved in regular high intensity physical activity
  • otherwise good health status

Exclusion criteria

twin pregnancy

Trial design

1,086 participants in 2 patient groups

Phase 1: Pregnant women
Phase 2: Mother-offspring dyad

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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