Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction (R²ACE)

Universiteit Antwerpen

Status: Completed

Conditions: Myocardial Infarction; Reperfusion Injury

Study type: Observational

Funder types: Other

Identifiers

NCT01414452

UAntwerpen

Details and patient eligibility

About

There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on remodeling, mainly through stimulation of neo-revascularisation. Clinical data on these issues are lacking. This clinical project studies the role of adiponectin, endothelial progenitor cells and endothelial microparticles in the ischaemia-reperfusion process and the compensatory ventricular remodelling in a population of 250 infarction patients treated with primary PCI. If the role of these factors could be confirmed in this clinical setting, those factors might represent a new target for therapeutic interventions in AMI patients.

Enrollment: 250 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• STEMI treated with primary PCI

Exclusion criteria

• ischemia time >12h
• use of immunosuppressive therapy
• unsuccessful recanalisation
• not-interpretable ST-T segment

Trial design

250 participants in 1 patient group

STEMI patients

Description:

Patients with ST elevation myocardial infarction,lasting \<12 hour, who were succesfully treated with primary PCI