Role of Altered CD40-Ligand Gene Transcription in Systemic Lupus Erythematosus

National Center for Research Resources (NCRR)

Status: Unknown

Conditions: Lupus Erythematosus, Systemic

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00008749

NCRR-M01RR00240-1736

Details and patient eligibility

About

Systemic lupus erythematosus is an often devastating autoimmune disease which affects 1 in 2,000 women in the United States. Recently, several research laboratories have reported that a protein, named CD40-ligand (CD154), is overexpressed by a subset of white blood cells, called lymphocytes, in patients with lupus. Expression of CD154 appears critical to the generation of antibodies that cause disease in lupus. Blocking CD154 interactions in the immune system has been shown to decrease disease activity in animal models of lupus. We propose to study the regulation of CD154 in patients with lupus in hopes of inhibiting its abnormal and deleterious expression.

Sex: All

Ages: 13+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion:

A diagnosis of systemic lupus erythematosus