Role of Angiotensin II in Insulin-induced Microvascular Activity

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Microcirculation; Insulin Sensitivity

Treatments: Drug: Angiotensin II; Drug: Placebo; Drug: Phenylephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT01024543

MEC 06-2-074

Details and patient eligibility

About

In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?

Enrollment: 18 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1.18-60 years 2.Caucasian 3.Blood pressure <140/90 mmHg.

Exclusion criteria

1. Obesity (BMI>27kg/m2)
2. Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
3. Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
4. Smoking
5. Alcohol use >4U/day
6. Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
7. Pregnancy
8. Wearing contact lenses

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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18 participants in 3 patient groups

Placebo

Sham Comparator group

Description:

Placebo

Treatment:

Drug: Placebo

Angiotensin II

Experimental group

Description:

Angiotensin II

Treatment:

Drug: Angiotensin II

Phenylephrine

Active Comparator group

Description:

Phenylephrine

Treatment:

Drug: Phenylephrine