Role of Antibiotics Post Tonsillectomy

Assiut University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Tonsillectomy

Treatments: Drug: Amoxicillin/clavulanate

Study type: Interventional

Funder types: Other

Identifiers

NCT03491085

Antibiotics with tonsillectomy

Details and patient eligibility

About

morbidity after tonsillictomy remains asignificant problem therefore they recommend prophylactic antibiotics to reduce it.in the other hand, the overuse of antimicrobial agents can lead to antimicrobial resistance ,adverse drug events,and unnecessary cost.so,the effectiveness and necessity of antibiotic following tonsillictomy needs to be studied .

Enrollment: 200 estimated patients

Sex: All

Ages: 1 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

200 patients who are scheduled for tonsillectomy with or without adenoidectomy, and their age are less than 18 years old of either gender will be included in our study

Exclusion criteria

• 1-Patients age ≥ 18 years.

  2-Trials in which antibiotics was administrated locally or used in the immediate preoperative period (within seven days before surgery).

  3. Medical comorbidity requiring treatment with antibiotics e.g. Rheumatic heart disease

  4-Patients undergoing the following procedures:

  1. Unilateral tonsillectomy or biopsy.
  2. Tonsillectomy for known carcinoma.
  3. Tonsillectomy in conjunction with palatal surgery.
  4. Hot tonsillectomy for tonsillar abscess

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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200 participants in 2 patient groups

tonsillictomy with antibiotics

Active Comparator group

Treatment:

Drug: Amoxicillin/clavulanate

tonsillictomy Without Antibiotics

No Intervention group