Role of Auditory Cortical Oscillations in Speech Processing and Dyslexia

University of Geneva, Switzerland

Status: Completed

Conditions: Dyslexia

Treatments: Device: Transcranial alternating current stimulation

Study type: Interventional

Funder types: Other

Identifiers

NCT04277351

PHONOSTIM

Details and patient eligibility

About

This study aims at investigating the role of low-gamma activity in phonemic encoding and its implication in dyslexia. Indeed, a phonological deficit, i.e. a difficulty in perceiving the sounds of speech, is strongly suspected in dyslexia but has never been conclusively associated with a specific underlying mechanism.

The study employs transcranial alternating current stimulation in adults with and without dyslexia to exploit the effect of the stimulation on phonemic processing and neural activity measured with electroencephalography. In doing so, it would be possible to establishing a causal link between gamma oscillations and the phonological deficit in dyslexia.

Enrollment: 30 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-65 years old;
• French native speakers;
• normally-hearing;
• intellectual quotient (IQ) around average;
• for the dyslexia group: previous diagnosis of dyslexia as assessed by a speech therapist.

Exclusion criteria

• Presence of metal or electronic implants in the brain/skull;
• Presence of metal or electronic device at other in other parts of the body;
• Have experienced a seizure or a loss of consciousness or a severe head trauma;
• Severe brain related illness ;
• Intake of central nervous system-effective medication;
• Pregnant and nursing women;
• Relatives affected by epilepsy.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Single Blind

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30 participants in 1 patient group

tACS in individuals with and without dyslexia

Experimental group

Description:

Each participant in both the group of normo-readers and individuals with dyslexia receive all tACS stimulation conditions (fixed frequencies and sham) over different experimental days.

Treatment:

Device: Transcranial alternating current stimulation