Role of Biomarkers in Disease Progression in Samples From Patients With Acute Myeloid Leukemia

Children's Oncology Group

Status

Completed

Conditions

Leukemia

Treatments

Other: mass spectrometry

Genetic: western blotting

Genetic: protein analysis

Genetic: gene rearrangement analysis

Genetic: polymerase chain reaction

Other: laboratory biomarker analysis

Genetic: gene expression analysis

Study type

Observational

Funder types

NETWORK

NIH

Identifiers

NCT01500499

AAML12B2 (Other Identifier)

COG-AAML12B2 (Other Identifier)

NCI-2012-00099 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies the role of biomarkers in disease progression in samples from patients with acute myeloid leukemia.

Full description

OBJECTIVES:

To determine the subcellular localization of the MLL-AF1q fusion protein in leukemia cells.

OUTLINE: Cryopreserved specimens are analyzed for MLL-AF1q fusion protein and AF1 gene expression by mass spectrometry, western blot analysis, semi-quantitative PCR, and qPCR.

Enrollment

20 estimated patients

Sex

All

Ages

Under 30 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS: