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Role of Biomarkers in Patients Undergoing Dialysis Treatment (DRYWEIGHT)

University of Zurich (UZH) logo

University of Zurich (UZH)

Status

Completed

Conditions

Volemia in Dialysis Patients

Treatments

Device: bioelectrical impedance measurement and biomarker measurement

Study type

Observational

Funder types

Other

Identifiers

NCT02962635
DRYWEIGHT

Details and patient eligibility

About

A precise volume status assessment is critical to improve outcome of patients on dialysis. Yet, accurate assessment of fluid status remains a challenge. Currently, this is performed by clinical evaluation and regular weight measurements before and after dialysis, which is not always accurate. Moreover, bioimpedance technology is used in some centers for quantitative assessment of total body water. This approach has been validated for the assessment of volume status in dialysis patients, but requires the acquisition of specific tools and is time consuming. So far, no biomarker has been validated to quantify volume status in dialysis patients. Application of biomarkers might contribute to a better dialysis prescription and therefore to outcome improvement in dialysis. The investigators aim to investigate the role of a novel biomarkers (sCD146) to assess volume status in dialysis patients

Enrollment

45 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age > 18 years old
  • Patient on dialysis since > 1 month
  • Voluntarily signed informed consent

Exclusion criteria

  • Pregnant or breastfeeding women and women who plan to get pregnant during study
  • Incapability of following the study protocol
  • Acute illness
  • Hospitalizations in the last week before inclusion
  • Cardiac pacemakers or defibrillators
  • Limb amputation or other factors precluding a reliable bioimpedance measurement (unreliable bioimpedance measurement)

Trial design

45 participants in 2 patient groups

Hemodialysis patients
Description:
A total of 30 patients - measuring volume status by bioelectrical impedance measurement as well as clinical evaluation and comparing with the novel biomarker
Treatment:
Device: bioelectrical impedance measurement and biomarker measurement
Peritoneal dialysis patients
Description:
A total of 15 patients - measuring volume status by bioelectrical impedance measurement as well as clinical evaluation and comparing with the novel biomarker
Treatment:
Device: bioelectrical impedance measurement and biomarker measurement

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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