Role of Biomarkers in Patients Undergoing Dialysis Treatment (DRYWEIGHT)

University of Zurich (UZH)

Status: Completed

Conditions: Volemia in Dialysis Patients

Treatments: Device: bioelectrical impedance measurement and biomarker measurement

Study type: Observational

Funder types: Other

Identifiers

NCT02962635

DRYWEIGHT

Details and patient eligibility

About

A precise volume status assessment is critical to improve outcome of patients on dialysis. Yet, accurate assessment of fluid status remains a challenge. Currently, this is performed by clinical evaluation and regular weight measurements before and after dialysis, which is not always accurate. Moreover, bioimpedance technology is used in some centers for quantitative assessment of total body water. This approach has been validated for the assessment of volume status in dialysis patients, but requires the acquisition of specific tools and is time consuming. So far, no biomarker has been validated to quantify volume status in dialysis patients. Application of biomarkers might contribute to a better dialysis prescription and therefore to outcome improvement in dialysis. The investigators aim to investigate the role of a novel biomarkers (sCD146) to assess volume status in dialysis patients

Enrollment: 45 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age > 18 years old
• Patient on dialysis since > 1 month
• Voluntarily signed informed consent

Exclusion criteria

• Pregnant or breastfeeding women and women who plan to get pregnant during study
• Incapability of following the study protocol
• Acute illness
• Hospitalizations in the last week before inclusion
• Cardiac pacemakers or defibrillators
• Limb amputation or other factors precluding a reliable bioimpedance measurement (unreliable bioimpedance measurement)

Trial design

45 participants in 2 patient groups

Hemodialysis patients

Description:

A total of 30 patients - measuring volume status by bioelectrical impedance measurement as well as clinical evaluation and comparing with the novel biomarker

Treatment:

Device: bioelectrical impedance measurement and biomarker measurement

Peritoneal dialysis patients

Description:

A total of 15 patients - measuring volume status by bioelectrical impedance measurement as well as clinical evaluation and comparing with the novel biomarker

Treatment:

Device: bioelectrical impedance measurement and biomarker measurement