Role of Calcium Binding Protein S100A12 in Diagnosis and Prognosis of Kawasaki Disease

The First Affiliated Hospital of Yangtze University

Status: Not yet enrolling

Conditions: Diagnoses Disease

Treatments: Diagnostic Test: S100A12

Study type: Observational

Funder types: Other

Identifiers

NCT05434611

PYan

Details and patient eligibility

About

Recent studies showed that the value of c100A12 increased in children with Kawasaki disease, and decreased rapidly after treatment with gamma globulin. In kawasaki disease with coronary artery dilatation, S100A12 levels are elevated in the acute phase of Kawasaki disease and continue for some time in the convalescence phase before gradually decreasing. However, the number of patients included in previous studies was small and the follow-up time was short. In this study, 100 children with Kawasaki disease who were admitted to Wuhan Children's Hospital, Jingzhou First People's Hospital and Renhe Hospital affiliated to China Three Gorges University from December 2021 to December 2023 were selected as the research objects, and 100 children with healthy physical examination were selected as the control group during the same period. To investigate whether S100A12 increased significantly in the acute phase of Kawasaki disease compared with a healthy control group. To study whether S100A12 value increased rather than decreased in kawasaki disease that did not respond to gamma globulin treatment after gamma globulin treatment. At the same time, to study whether the increase of S100A12 in kawasaki disease convalescence indicates coronary aneurysm.

Full description

S100A12 was determined using the ELISA kit and according to the instructions.

Enrollment: 100 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

▪Diagnostic criteria of Kawasaki disease revised by the American Heart Association in 2017

Exclusion criteria

• Scarlet fever
• Drug allergy syndrome
• Stevens-Johnson syndrome
• Toxic shock syndrome
• Adenovirus infection
• Epstein-Barr(EB) virus infection

Trial design

100 participants in 2 patient groups

Kawasaki disease

Description:

All children with Kawasaki disease met the diagnostic criteria for Kawasaki disease revised by the American Heart Association in 2017.

Treatment:

Diagnostic Test: S100A12

Healthy controls

Description:

Healthy control group were healthy children who underwent outpatient physical examination.

Treatment:

Diagnostic Test: S100A12