Role of Calcium Channels in Vascular Function

University of Southern Denmark (SDU)

Status: Completed

Conditions: Endothelium, Vascular

Treatments: Drug: Nifedipine; Drug: Efonidipine

Study type: Interventional

Funder types: Other

Identifiers

NCT02885558

47880

Details and patient eligibility

About

The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.

Enrollment: 12 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age 20 - 30 and 60-70
• BMI < 30

Exclusion criteria

• Hypertension (>150/90 mmHg)
• Smoking
• Physical activity >2 hours/week
• Known chronic diseases
• Pregnancy or birth within 3 month
• Alcohol misuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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12 participants in 2 patient groups

L + T-type

Experimental group

Description:

8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)

Treatment:

Drug: Efonidipine

L-Type

Active Comparator group

Description:

8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)

Treatment:

Drug: Nifedipine