Role of Calcium Channels in Vascular Function

U

University of Southern Denmark

Status

Completed

Conditions

Endothelium, Vascular

Treatments

Drug: Nifedipine
Drug: Efonidipine

Study type

Interventional

Funder types

Other

Identifiers

NCT02885558
47880

Details and patient eligibility

About

The purpose of this study is to examine the role of T-type calcium channels in endothelial dysfunction observed with ageing.

Enrollment

12 patients

Sex

All

Ages

20 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • age 20 - 30 and 60-70
  • BMI < 30

Exclusion criteria

  • Hypertension (>150/90 mmHg)
  • Smoking
  • Physical activity >2 hours/week
  • Known chronic diseases
  • Pregnancy or birth within 3 month
  • Alcohol misuse

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

12 participants in 2 patient groups

L + T-type
Experimental group
Description:
8 weeks treatment with efonidipine (1 week 1x20mg, 7 weeks 2x20mg)
Treatment:
Drug: Efonidipine
L-Type
Active Comparator group
Description:
8 weeks treatment with nifedipine (1 week 1x20mg, 7 weeks 2x20mg)
Treatment:
Drug: Nifedipine

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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