Role of CCL2 in Alcoholic Liver Diseases

Free University of Brussels (ULB)

Status: Completed

Conditions: Alcoholic Liver Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01128010

DD-CCL2

Details and patient eligibility

About

Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

ALD patients

Inclusion Criteria:

• Excess alcohol intake
• Abnormality of liver biopsy compatible with alcoholic aetiology
• Caucasian ethnicity

Exclusion Criteria:

• Presence of any other chronic liver disease
• co-infection with HIV Controls Inclusion criteria
• Caucasian ethnicity
• presence of a disease

Trial design

0 participants in 2 patient groups

alcoholic liver disease

Description:

alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution

controls

Description:

Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination