Role of Colonic Events on Metabolism and Appetite Control: A Synbiotic Approach

Lund University

Status and phase: Completed; Early Phase 1

Conditions: Obesity; Metabolic Syndrome

Treatments: Other: reference; Other: test meal

Study type: Interventional

Funder types: Other

Identifiers

NCT01718418

Dnr2010/457

Details and patient eligibility

About

The purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.

Enrollment: 21 patients

Sex: All

Ages: 20 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal fasting blood glucose, BMI 19-25 kg/m2, for women: hormon based contraceptives

Exclusion criteria

• gastrointestinal diseases or food allergies e.g. lactose-, gluten intolerance, metabolic disorders e.g. diabetes, tobacco/snuff users. Antibiotic or probiotic usage within two weeks, and during the study. Vegetarians

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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21 participants in 3 patient groups

+ ind.CHO + prebiotics

Experimental group

Description:

test meal: intrinsic indigestible carbohydrates in combination with a combined probiotic supplement.

Treatment:

Other: test meal

+ ind.CHO - prebiotics

Experimental group

Description:

test meal: intrinsic indigestible carbohydrates in combination with placebo probiotic supplement.

Treatment:

Other: test meal

- ind.CHO - prebiotics

Experimental group

Description:

reference: no ind. carbohydrates and no probiotic supplement

Treatment:

Other: reference