Role of Colonic Short Chain Fatty Acids in Obesity

University of Toronto

Status: Completed

Conditions: Obesity

Treatments: Other: Inulin; Other: Glucose; Other: Resistant Starch

Study type: Interventional

Funder types: Other

Identifiers

NCT02562014

Protocol #27112

Details and patient eligibility

About

The excess production of colonic short-chain-fatty-acids (SCFA) has been implicated in the promotion of obesity, but colonic fermentation of dietary-fiber to SCFA may also play a role in preventing diabetes. The investigators aimed to compare the effects of two fermentable fibers (inulin and resistant-starch) on postprandial SCFA, glucose, insulin, free-fatty acids (FFA) and gut hormone responses and to compare the responses in healthy overweight and obese (OWO) vs lean (LN) participants. Methods: Using a randomized, single blind, crossover design, 13 OWO and 12 LN overnight fasted participants were studied on 3 separate occasions. On each day they consumed a 300 mL drink containing 75g glucose (Control) or 75g glucose plus 24g inulin (IN), or 28.2g resistant-starch (RS). A standard lunch was served 4 h after the test drink.

Enrollment: 25 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• non-pregnant
• body mass index >=20 and <=35

Exclusion criteria

• history of diabetes mellitus
• history of cardiovascular disease
• history of bowel disease
• history of kidney disease
• history of liver disease
• use of antibiotics within 3 months of enrolment
• unusual dietary habits
• fasting glucose >6.9mmol/L
• hematocrit below normal range for age and sex

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

Lean

Other group

Description:

Participants with body mass index \<=25

Treatment:

Other: Glucose

Other: Inulin

Other: Resistant Starch

Overweight

Other group

Description:

Participants with body mass index \>25

Treatment:

Other: Glucose

Other: Inulin

Other: Resistant Starch