Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients

Civil Hospices of Lyon

Status: Completed

Conditions: Parkinson Disease

Treatments: Other: Neuropsychological detailed tests with focus on social cognition

Study type: Interventional

Funder types: Other

Identifiers

NCT03004573

2016-A00143-48 (Other Identifier)

69 HCL15_0760

Details and patient eligibility

About

Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
• Social insurance

Exclusion criteria

• No affiliation to the social insurance
• Patients under guardianship

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

Deep brain stimulation

Experimental group

Treatment:

Other: Neuropsychological detailed tests with focus on social cognition