Role of Diaphragm Fatigue in Weaning From Mechanical Ventilation

University Medical Center Nijmegen

Status: Unknown

Conditions: Respiratory Muscle Function; Weaning

Study type: Observational

Funder types: Other

Identifiers

NCT01135121

Wean1

Details and patient eligibility

About

The purpose of this study is to determine whether the diaphragm develops contractile fatigue during a weaning trial and if this is associated with weaning failure.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age > 18 year
• mechanical ventilation for at least 3 days
• the treating physician judges the patient to be ready to be weaned from the ventilator
• informed consent

Exclusion criteria

• pre-existent muscle disease (congenital or acquired) or diseases / disorders know to be associated with myopathy including auto-immune diseases.
• upper airway / esophageal pathology (i.e. recent surgery, esophageal varices, diaphragmatic hernia)
• recent (< 1 month) nasal bleeding
• phrenic nerve lesions

Trial design

20 participants in 2 patient groups

Weaning failure

Weaning succes