Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance (HEPFAT)

Uppsala University

Status: Completed

Conditions: Fatty Liver; Diabetes; Insulin Resistance; Obesity

Treatments: Other: SFA diet; Other: PUFA Diet

Study type: Interventional

Funder types: Other

Identifiers

NCT01038102

CKFUU-45521 (Other Grant/Funding Number)

FAS-2008-1364

Details and patient eligibility

About

The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects

Full description

Specific goals:

1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes
2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content
3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity

Enrollment: 65 patients

Sex: All

Ages: 30 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• abdominal obese subjects with or without type 2 diabetes
• sagittal abdominal diameter >25cm

Exclusion criteria

• insulin treatment
• history of serious cardiovascular events
• morbid obesity
• claustrophobia (relative criterion)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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65 participants in 2 patient groups

PUFA diet

Active Comparator group

Description:

Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%)

Treatment:

Other: PUFA Diet

SFA diet

Active Comparator group

Description:

Diet high in saturated fat (15 E%)

Treatment:

Other: SFA diet