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Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance (HEPFAT)

U

Uppsala University

Status

Completed

Conditions

Fatty Liver
Diabetes
Insulin Resistance
Obesity

Treatments

Other: SFA diet
Other: PUFA Diet

Study type

Interventional

Funder types

Other

Identifiers

NCT01038102
CKFUU-45521 (Other Grant/Funding Number)
FAS-2008-1364

Details and patient eligibility

About

The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects

Full description

Specific goals:

  1. Investigate if substituting saturated fats with polyunsaturated fats reduces steatosis and improves hepatic and/or peripheral insulin action in abdominally obese subjects with type 2 diabetes
  2. Investigate if changes of lipogenic enzymes in response to dietary fat intervention are associated with changes in hepatic/peripheral insulin sensitivity or liver fat content
  3. Investigate potential mechanism of the effects of dietary fatty acids; e.g. gene expression and lipogenic enzyme activity

Enrollment

65 patients

Sex

All

Ages

30 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • abdominal obese subjects with or without type 2 diabetes
  • sagittal abdominal diameter >25cm

Exclusion criteria

  • insulin treatment
  • history of serious cardiovascular events
  • morbid obesity
  • claustrophobia (relative criterion)

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

65 participants in 2 patient groups

PUFA diet
Active Comparator group
Description:
Diet high in polyunsaturated (rich in linoleic acid, omega-6) fat (15 E%)
Treatment:
Other: PUFA Diet
SFA diet
Active Comparator group
Description:
Diet high in saturated fat (15 E%)
Treatment:
Other: SFA diet

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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