Role of Dietary Protein Intake in Elderly Adults

University of Arkansas

Status

Completed

Conditions

Protein Overload

Treatments

Other: Elevated protein intake

Other: Recommended protein intake

Study type

Interventional

Funder types

Other

Identifiers

NCT03765710

204291

Details and patient eligibility

About

The investigators examined the effects of dietary protein intake in a mixed meal at two levels of protein amount on whole body protein metabolisms in older adults.

Full description

The investigators determined the total anabolic response to an amount of protein intake commonly eaten with dinner (70g) as compared with the amount required to maximally stimulate muscle protein synthesis (35g). Men and women, ages > 60 years will be studied under two levels of protein intake in mixed meals in random order (35g or 70g protein in isocaloric mixed meals). For two days prior to each stable isotope tracer study, subjects' dietary intake of calories and protein will be stabilized by providing subjects their entire diets. On the third day, a 8-hr metabolic study will be conducted in the UAMS Reynolds Institute on Aging (IOA) to determine the total anabolic response to the particular amount of beef intake, which will be repeated with the other amount of protein in mixed meal after a minimum 7-day washout interval. The investigators measured whole body protein kinetics, muscle fractional synthetic rate, and plasma amino acid profile.

Enrollment

8 patients

Sex

All

Ages

60+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Men and women, ages > 60 years

Exclusion criteria

History of diabetes
History of malignancy in the 6 months prior to enrollment
History of gastrointestinal bypass surgery (Lapband, etc)
History of a chronic inflammatory condition or disease (Lupus, HIV/AIDS, etc)
Pregnant females
Subjects who do not or will not eat animal proteins
Subjects who cannot refrain from consuming protein or amino acid supplements during their participation in this study
Subjects who report regular resistance exercise (more than once per week)
Hemoglobin less than 9.5 mg/dL at the screening visit
Platelets less than 150,000 at the screening visit
Subjects who are not willing or able to suspend aspirin for several days prior to their muscle biopsies
Subjects who have been prescribed a blood-thinning medication (Coumadin, lovenox, heparin, Plavix, etc.)
Concomitant use of corticosteroids (ingestion, injection or transdermal)
Any other disease or condition that would place the subject at increased risk of harm if they were to participate, at the discretion of the study physician