Role of Dietary Protein on Satiety, Food Intake and Thermic Effect of Food

Toronto Metropolitan University

Status: Completed

Conditions: Overweight; Obesity

Treatments: Other: Low Protein Meal; Other: Control Meal; Other: High Protein Meal; Other: Moderate Protein Meal

Study type: Interventional

Funder types: Other

Identifiers

NCT02200796

tempID

Details and patient eligibility

About

Objectives: To determine the effect of protein content of familiar breakfast meals on subjective appetite, food intake (FI), glycemic response and Thermic Effect of Food (TEF) in normal weight (NW) and overweight (OW)/obese (OB) children.

Specific Objectives:

1a.To determine the effect of familiar breakfast meals (450 kcal containing eggs and varying in protein content (15, 30, and 45g) on subjective appetite, glycemic response and food intake at a test meal 4 h later in NW and. OW/OB children.

1b. To describe the effect of isocaloric (450 kcal) familiar breakfasts either high in protein (optimal protein from Objective 1a) or low in protein on TEF and substrate utilization over 5 h in NW and OW/OB children.

Full description

Hypothesis: The investigators hypothesize that increasing the high-quality protein content of a breakfast meal will dose dependently increase subjective satiety, lower FI and glycemic response, and increase the TEF in both NW and OW/OB children.

Enrollment: 17 patients

Sex: All

Ages: 9 to 14 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Boys and girls between the ages of 9 and 14 y
• Only peri-pubertal girls
• Normal body weight (between the 5th and 85th BMI percentile for age and gender)
• OW/OB (>85th BMI percentile for age and gender)

Exclusion criteria

• Food sensitivities
• Food allergies
• Dietary restrictions
• Health, learning, emotional or behavioural problems
• On any medication

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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17 participants in 4 patient groups

Low Protein Meal

Experimental group

Description:

Low Protein Test Meal (15 g)

Treatment:

Other: Low Protein Meal

Moderate Protein Meal

Experimental group

Description:

Moderate Protein Meal (30 g)

Treatment:

Other: Moderate Protein Meal

High Protein Meal

Experimental group

Description:

High Protein Meal (45g)

Treatment:

Other: High Protein Meal

Control Meal

Experimental group

Description:

High Carbohydrate Control Meal (7 g of protein)

Treatment:

Other: Control Meal