Electro-physiological Findings and Symptoms Severity in Superior Canal Dehiscence (INTEX-DEHI)

Toulouse University Hospital

Status

Not yet enrolling

Conditions

Superior Semicircular Canal Dehiscence

Treatments

Diagnostic Test: Vestibular Evoked Myogenic potentials

Diagnostic Test: Wideband tympanometry

Diagnostic Test: Electrocochleography

Study type

Interventional

Funder types

Other

Identifiers

NCT06170398

RC31/22/0322

2023-A01856-39 (Other Identifier)

Details and patient eligibility

About

This research aims at assessing the validity of three different electro-physiological tests (Vestibular Evoked Myogenic Potentials, WideBand Tympanometry, Electrocochleography) used in the investigation of the symptoms severity in the case of superior semi-circular canal dehiscence syndrome.

Full description

Superior semi-circular canal dehiscence (SCD) syndrome can associate several cochlear and vestibular symptoms. Recent systematic reviews identified pulsatile tinnitus, autophony, sound-induced and pressure-induced vertigo as most specific signs of SCD. These signs are rarely all present and the symptomatology remains highly variable from a patient to another, with frequent though less evocative symptoms such as dizziness or ear pressure. A surgical treatment may be proposed when the symptoms become significantly incapacitating. Unfortunately to date, there is no objective marker of this severity and all surgical decisions rely on the importance of patients' complaints. High Resolution Computed Tomography (HRCT) of the temporal bone can confirm the diagnosis. Electro-physiological investigations such as Vestibular Evoked Myogenic potentials (VEMPs) have also been extensively described in the diagnosis of SCD but they have been reported as independent from the symptoms severity. Wideband tympanometry (WBT) and Electrocochleography (EcoG) have only been studied in few reports but the latter appears as a promising tool in the assessment of the symptoms because it explores inner ear biomechanics, directly involved in the pathophysiology of this condition.

Enrollment

115 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

confirmed unilateral SCD (using specific HRCT settings and reconstructions) with or without SCD symptoms
if present, SCD symptoms should be stable
patients understanding and reading french
affiliated to social security.

Exclusion criteria

bilateral confirmed SCD
doubtful SCD
other otologic or neurotologic condition that might mimick SCD symptomatology : middle ear conditions, Meniere disease, vestibular migraine