Role of Endocrine Disruptors in Thyroid Cancer (THY-ED)

Istituto Auxologico Italiano

Status: Enrolling

Conditions: Thyroid Cancer; Endocrine Disruptor Chemicals

Treatments: Diagnostic Test: Blood and urine diagnostic evaluation

Study type: Observational

Funder types: Other

Identifiers

NCT05747365

05C214

Details and patient eligibility

About

the relationship between human exposure to EDCS and TC is poorly investigated and still unclear. The aim of this study is to evaluate the possible role of old and new generation endocrine disruptors in thyroid cancer. The primary aim is to evaluate the difference in the average levels of the main endocrine disruptors (PFAS, including: PFOA, PFOS, PFDA, PFUnA, PFHpS and possibly subsequently other categories, such as bisphenols, phthalates, parabens, PCBs, flame retardants) between patients with and without a diagnosis of thyroid cancer through highly sensitive, selective and precise mass spectrometry methods, such as liquid chromatography combined with tandem mass spectrometry (LC-MS / MS).

The secondary aim is to evaluate the relationship between the concentrations of endocrine disruptors and some anamnestic variables studied (for example the type of diet, the use of personal care products).

Enrollment: 222 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with a diagnosis of thyroid cancer in the last 5 years (arm A)
• patients without a diagnosis of thyroid cancer will match patients included in arm A

Exclusion criteria

• subjects under 18 years old
• patients unable to sign the informed consent or questionnaires

Trial design

222 participants in 2 patient groups

Case group

Description:

Patients with thyroid cancer diagnosis within 5 years before study enrollment

Treatment:

Diagnostic Test: Blood and urine diagnostic evaluation

Control group

Description:

Patients without clinical diagnosis of thyroid disease

Treatment:

Diagnostic Test: Blood and urine diagnostic evaluation