Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

National Taiwan University

Status: Unknown

Conditions: Chronic Heart Failure; Coronary Disease; Dilated Cardiomyopathy

Study type: Observational

Funder types: Other

Identifiers

NCT01139086

201003050R

Details and patient eligibility

About

Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are

1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living
2. to compare endothelium function between CHF patients and healthy control subjects
3. the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Enrollment: 100 estimated patients

Sex: Male

Ages: 40 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 40-75 years
• Chronic heart failure: ejection fraction<40% and at stable condition
• Coronary Disease and dilated cardiomyopathy without heart failure
• Control group without diagnosis of any heart disease

Exclusion criteria

• Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study

Trial design

100 participants in 3 patient groups

Cardiovascular disease

Description:

Diagnosis of cardiomyopathy or ischemic heart disease without heart failure

Chronic heart failure

Description:

Diagnosis of cardiomyopathy or ischemic heart disease LVEF \<40%

Control

Description:

Age and body built matched with chronic heart failure group