Role of Fcgamma Receptors in Immune Thrombocytopenia (ITP) (PTI Fc)

University Hospital Center (CHU) Dijon Bourgogne

Status

Enrolling

Conditions

Immune Thrombocytopenia

Treatments

Biological: blood sample

Procedure: spleen sample

Study type

Observational

Funder types

Other

Identifiers

NCT02821572

BONNOTTE PARI 2013

Details and patient eligibility

About

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a peripheral destruction of platelets responsible for bleedings.

Monocytes/macrophages play a double role by phagocyting platelets recognized by autoantibodies and by maintaining the autoimmune response via their antigen-presenting cell functions.

Fcgamma receptors (FcγR), that are represented by activating receptors (FcγRI, FcγRIIa, FcγRIII) and an inhibiting one (FcγRIIb), are involved in the regulation of macrophages and have been reported to be dysregulated in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematous.

The aim of this study is to compare the expression of FcγR in patients with ITP on circulating monocytes and on splenic macrophages.

Enrollment

70 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

ITP group

Patients who have provided written consent
Patients over 18 years
Patients with national health insurance
Patients with ITP, defined as thrombocytopenia < 100 G/L, after exclusion of infection- or drug-related thrombocytopenia and malignant hemopathy.

Control Group