Role of Femoral Nerve Block on Prevention of Postoperative Deep Venous Thromboembolism

General Hospital of Ningxia Medical University

Status: Unknown

Conditions: Gonarthrosis

Treatments: Procedure: femoral nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT02411097

CJGG2014

Details and patient eligibility

About

To investigate whether preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.

Full description

Femoral nerve block is an effective analgesic mode in patients after total knee arthroplasty. In recent studies, there has been shown that a large amount of neutrophil elastase release from neutrophils could induce the development of deep venous thromboembolism and femoral nerve block may reduce the incidence of the development of deep venous thromboembolism. In addition, inflammatory cytokines including interleukin-1(IL-1), IL-6, IL-8 and tumor necrosis factor(TNF) were associated with deep venous thromboembolism. Thus, the investigators hypothesised that preemptive analgesic of femoral nerve block could prevent deep venous thromboembolism due to inhibiting the excessive release of neutrophil elastase and inflammatory cytokines.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients scheduled for total knee arthroplasty under general anesthesia

Exclusion criteria

• ASA physical status Ⅳ-Ⅴ,
• psychiatric illness,
• chronic opioid consumption,
• patient refusal,
• coagulopathy,
• peripheral neurological injury,
• local anesthesia drug allergy,
• preoperative existing deep venous thromboembolism.

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: Double Blind

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120 participants in 1 patient group

femoral nerve block

Experimental group

Description:

femoral nerve block will be administered before or after the surgery

Treatment:

Procedure: femoral nerve block