Role of Gut Microbiome in Cancer Therapy

Mayo Clinic

Status: Enrolling

Conditions: Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm

Treatments: Procedure: Biospecimen Collection; Other: Electronic Health Record Review

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05112614

NCI-2021-10793 (Registry Identifier)

19-003060 (Other Identifier)

Details and patient eligibility

About

This study examines how gut microbiome can affect cancer therapy in cancer patients undergoing cancer therapy or stem cell transplant. The human microbiome affects the way some cancer drugs are metabolized in the human body. Information from this study may help doctors improve the way cancer treatment is delivered, and increase its effectiveness and success.

Full description

PRIMARY OBJECTIVE:

I. To correlate gut microbiome with specific cancer diagnoses and the clinical response (efficacy), and adverse effects of cancer therapy (single or multiple) and stem cell transplant.

OUTLINE:

Patients undergo collection of blood and stool samples and have their medical records reviewed.

Enrollment: 3,000 estimated patients

Sex: All

Ages: 18 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18-99
• Diagnosis of cancer and undergoing cancer therapy or scheduled to start cancer therapy or undergoing stem cell transplant for any hematological condition

Exclusion criteria

• Unable to provide informed consent
• Vulnerable adults

Trial design

3,000 participants in 1 patient group

Observational (biospecimen collection, medical record review)

Description:

Patients undergo collection of blood and stool samples and have their medical records reviewed.

Treatment:

Other: Electronic Health Record Review

Procedure: Biospecimen Collection