Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation

National and Kapodistrian University of Athens

Status and phase: Completed; Phase 3; Phase 2

Conditions: Infertility

Treatments: Drug: no heparin; Drug: Heparin, Low-Molecular-Weight

Study type: Interventional

Funder types: Other

Identifiers

NCT01315093

123456

Details and patient eligibility

About

The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)

Enrollment: 50 patients

Sex: Female

Ages: 25 to 43 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• poor responders (age>40, abnormal ovarian test, </=4 oocytes in previous cycle with conventional stimulation)
• infertility, indication for IVF
• no contraindications for heparin

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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50 participants in 2 patient groups

Heparin, Low-Molecular-Weight group

Experimental group

Description:

LMWH was administered during an IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders. Drug was started at the beginning of the cycle and stopped at the time of pregnancy test if negative, or continued if pregnancy occurred until the 32th weeks of gestation

Treatment:

Drug: Heparin, Low-Molecular-Weight

Non Heparin, Low-Molecular-Weight group

Active Comparator group

Description:

IVF cycle using either the GnRH - agonist or antagonist protocol in poor responders.

Treatment:

Drug: no heparin