Role of High Mobility Group Box 1 as a Prognostic Biomarker in Patients Undergoing Off-pump Coronary Artery Bypass Graft

Yonsei University

Status: Completed

Conditions: Coronary Artery Occlusive Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02206412

4-2013-0341

Details and patient eligibility

About

High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein, and has recently been identified as a cytokine mediator of systemic inflammation. HMGB1 is released by inflammatory cells actively, or increased during cell death passively and mediates inflammatory response. It has been reported to have association with the prognosis after acute coronary syndrome, ischemia-reperfusion injury of myocardium, atherosclerosis and heart failure. This study aimed to investigate the relationship of serum levels of HMGB1 and post operative prognosis of patients who had undergone off-pump coronary artery bypass graft.

Enrollment: 255 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Age ≥ 20
2. Patients undergoing off-pump coronary artery bypass graft

Exclusion criteria

1. Age < 20
2. Patients undergoing off-pump coronary artery bypass graft with other simultaneous surgery
3. Patients participating other study

Trial design

255 participants in 1 patient group

HMGB1 group