Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP (RECAP-5)

Mass General Brigham

Status: Completed

Conditions: Aspirin-exacerbated Respiratory Disease; Nasal Polyps

Treatments: Other: Non-Interventional

Study type: Observational

Funder types: Other

Identifiers

NCT05672030

2003P002088

Details and patient eligibility

About

The overarching hypothesis of this proposal is that IL-5 acts on multiple sinus tissue cell types, including plasma cells and epithelial cells, to promote immune dysregulation, and that inhibition of IL-5 affects several relevant effector pathways that lead to clinical benefit.

Full description

Further characterization of the role of IL-5Rα expression and function on human plasma cells will determine whether inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to plasma cell proliferation. Further characterization of human upper airway epithelial cell IL-5Rα expression and function will determine whether or not inhibiting IL-5 signaling on these cells offers therapeutic promise in other diseases related to epithelial dysfunction. IL-5Rα expression has been identified on several relevant sinus tissue effector cells, including on nasal polyp plasma cells and epithelial cells, and the aim of this study is to further the field by determining the consequences of IL-5 signaling on those cells.

Enrollment: 30 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• AERD, CRSwNP, healthy controls

Exclusion criteria

• Not on any systemic steroids or respiratory biologics at time of surgery

Trial design

30 participants in 3 patient groups

Aspirin-exacerbated respiratory disease (AERD)

Description:

Aspirin-exacerbated respiratory disease (AERD)

Treatment:

Other: Non-Interventional

Aspirin-tolerant chronic rhinosinusitis with nasal polyps (CRSwNP)

Description:

Aspirin-tolerant chronic rhinosinusitis with nasal polyps (CRSwNP)

Treatment:

Other: Non-Interventional

Healthy controls

Description:

Individuals who do not have AERD or CRSwNP

Treatment:

Other: Non-Interventional