Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries

Noor-Ul-Ain

Status: Not yet enrolling

Conditions: Laparoscopic Surgery; Positive End Expiratory Pressure (PEEP); Pneumoperitoneum

Treatments: Other: Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries

Study type: Interventional

Funder types: Other

Identifiers

NCT06929078

HospitalBahawalpur

Details and patient eligibility

About

To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive end-expiratory pressure and conventional mechanical ventilation without positive end-expiratory pressure.

Full description

Thus study will compare the effects different methods of positive end-expiratory pressure administration in mechanical ventilation on respiratory parameters and oxygenation of the patients undergoing laparoscopic surgeries. There will be three groups of patients which will be as follows: Individualized positive end-expiratory pressure with recruitment maneuver group, fixed positive end-expiratory pressure group and conventional mechanical ventilation. Respiratory parameters; dynamic compliance, driving pressure and ratio of partial pressure of oxygen to fractional inspiration of oxygen will be measured. Mechanical ventilation respiratory parameters i .e. peak pressure, plateu pressure , dynamic compliance and driving pressure will be measured from ventilator machine. P/F ratio( Ratio of partial pressure of oxygen to inspiratory fraction of oxygen) will be measured by taking blood samples for arterial blood gas analysis.

Enrollment: 75 estimated patients

Sex: All

Ages: 25 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. Age Limit : 25 years to 65 years

  2. Patients undergoing laparoscopic suregeries

  3. ASA 1-3

Exclusion criteria

• 1. Hemodynamic instability 2. Bronchospam 3. Patients having COPD 4. History of pulmonary bulla 5. Patients having history of pneumothora

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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75 participants in 3 patient groups, including a placebo group

5cm of water Positive End-expiratory Pressure will be applied after induction of general anesthesia

Placebo Comparator group

Description:

A fixed positive end-expiratory pressure of 5cm of water will administered to the participants after induction of general anesthesia during mechanical ventilation undergoing laparoscopic surgeries.

Treatment:

Other: Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries

Individualized PEEP with recruitment maneuver guided by driving pressure measurement

Experimental group

Description:

Recruitment maneuver will be applied after induction of general anesthesia and indiviualized positive end-expiratory pressure will be applied guided by driving pressue during mechanical ventilation during laparoscopic surgeries.

Treatment:

Other: Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries

Conventional ventilation

No Intervention group

Description:

Conventional ventilation method without additional positive end-expiratory pressure will be applied to participants during mechanical ventilation undergoing laparoscopic surgeries.