Role of Indoor Pollutants on House Dust Mite Allergic Asthma

University Hospital, Strasbourg, France

Status: Withdrawn

Conditions: Allergy to House Dust Mite; Allergic Asthma

Treatments: Other: Formaldehyde and NO2 (Exposure to indoor pollutants); Other: Placebo (Exposure to indoor pollutants)

Study type: Interventional

Funder types: Other

Identifiers

NCT01019291

3965

Details and patient eligibility

About

It seems that the aldehydes and NO2, at the levels found indoor, could be the aggravating factors for an allergic response. However this effect has not been demonstrated. The investigators plan to study the effect of exposure to standard doses of these pollutants on the bronchial reactivity as measured by bronchial challenge tests with dust mite extract in volunteers asthmatic, allergic to house dust mite.

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• M/F 18-50 years of age
• History of intermittent HDM allergic asthma-FEV1 > 80%
• Non smokers or smokers with smoking < 10 PY

Exclusion criteria

• Persistent asthma and FEV1<80%
• Allergic to pets and pets at home

Trial design

0 participants in 4 patient groups, including a placebo group

NO2

Experimental group

Description:

NO2 400 µg/m3

Treatment:

Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

Formaldehyde

Experimental group

Description:

Formaldehyde 100 µg/m3

Treatment:

Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

NO2 + Formaldehyde

Experimental group

Description:

mixture of Formaldehyde and NO2

Treatment:

Other: Formaldehyde and NO2 (Exposure to indoor pollutants)

Placebo

Placebo Comparator group

Treatment:

Other: Placebo (Exposure to indoor pollutants)