Role of Inflammation in Carpal Tunnel Syndrome

Ahram Canadian University

Status: Not yet enrolling

Conditions: Carpal Tunnel Syndrome; Median Neuropathy, Carpal Tunnel

Treatments: Diagnostic Test: Inflammatory markers

Study type: Observational

Funder types: Other

Identifiers

NCT05852288

012/007075

Details and patient eligibility

About

This study aims to investigate the role of inflammation in carpal tunnel syndrome (CTS) using a prospective cohort study design. The study will involve a sample of at least 50 individuals with CTS who will undergo a comprehensive clinical and biochemical evaluation to assess the role of inflammation in CTS. The primary outcome measures include inflammatory markers, such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), as well as clinical measures of CTS severity. Data will be analyzed using regression analysis to determine the relationship between inflammation and CTS. The study is expected to provide information on the role of inflammation in CTS and inform the choice of drug and concentration for transdermal drug administration.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Individuals aged 18 years or older
• Diagnosis of carpal tunnel syndrome based on clinical symptoms and nerve conduction studies
• Willingness and ability to provide informed consent to participate in the study
• Willingness and ability to comply with study procedures and follow-up visits

Exclusion criteria

• Presence of other neurological conditions that may affect nerve function in the upper extremities
• Use of medications that may affect inflammation or carpal tunnel syndrome severity
• History of previous carpal tunnel release surgery on the affected wrist
• Inability to comply with study procedures or follow-up visits
• Pregnancy or breastfeeding

Trial design

50 participants in 1 patient group

Individuals with carpal tunnel syndrome

Description:

This study will follow a group of individuals with carpal tunnel syndrome (CTS) according to Bland's grading scale (grades 1-3) to assess the role of inflammation in CTS. Participants will undergo clinical and biochemical evaluations to assess inflammatory markers and CTS severity. The study will follow participants over time to determine the relationship between inflammation and CTS, which can inform the choice of transdermal drug administration.

Treatment:

Diagnostic Test: Inflammatory markers