Role of Instructions in Nitrous Oxide Effects and Choice - 10

The University of Chicago

Status: Completed

Conditions: Opioid-Related Disorders; Substance-Related Disorders

Treatments: Drug: Nitrous oxide 20% & placebo; Drug: Nitrous oxide 10% & placebo; Drug: Nitrous oxide 30% & placebo; Drug: Nitrous oxide 40% and placebo

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00000258

NIDA-08391-10

R01DA008391 (U.S. NIH Grant/Contract)

R01-08391-10

Details and patient eligibility

About

The purpose of this study is to conduct experiments to examine subjective and reinforcing effects of nitrous oxide. Mood altering and psychomotor effects will be tested on non-drug abusers and preference procedures will be used to assess reinforcing effects. Comparisons between nitrous oxide, opiates, and benzodiazepine antagonists will be made. To evaluate the role of instructions in nitrous oxide subjective effects and choice.

Enrollment: 22 patients

Sex: All

Ages: 21 to 32 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Please contact site for information.

Trial design

22 participants in 2 patient groups

Informed group

Active Comparator group

Description:

Group inhaled placebo and varying doses of nitrous oxide in pairs then chose which they wanted for a third inhalation.

Treatment:

Drug: Nitrous oxide 40% and placebo

Drug: Nitrous oxide 30% & placebo

Drug: Nitrous oxide 20% & placebo

Drug: Nitrous oxide 10% & placebo

Non-informed Group

Active Comparator group

Description:

Group and technician were blinded as to which gas they were inhaling in pairs with third inhalation subject's choice.

Treatment:

Drug: Nitrous oxide 40% and placebo

Drug: Nitrous oxide 30% & placebo

Drug: Nitrous oxide 20% & placebo

Drug: Nitrous oxide 10% & placebo