Role of Left Stellate Ganglion Block in Offering Myocardial Protection in On-pump Mitral Valve Replacement? A Histopathological and Clinical Assessment

Minia University

Status: Not yet enrolling

Conditions: Open Mitral Cardiac Surgery

Treatments: Procedure: sonar guided stellate ganglion block; Procedure: sonar guided stellate ganglion injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06476925

1130/4/2024

Details and patient eligibility

About

Can pre-operative left stellate ganglion block offer myocardial protection in on-pump mitral valve replacement? A histopathological and clinical assessment.

Enrollment: 100 estimated patients

Sex: All

Ages: 25 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult population of both sex, between 25-50 years, will undergo elective on pump mitral valve replacement

Exclusion criteria

• -Combined valve replacement ( mitral and aortic or mitral and tricuspid valves replacement).
• Emergency valve replacement ( stuck valve, infective endocarditis).
• Pre-operative cardiomyopathy (Ejection fraction less than 45%).
• Recent myocardial infarction ( within 6 months)
• Redo mitral valve replacement.
• Pre-operative pacing, or cardioverter, any form arrhythmia ( tachy or brady).
• Previous history of carotid endarterectomy or presence of carotid stent.
• On thrombolytic therapy.
• Severe chronic obstructive airway disease,
• Patient refusal

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Control group

Placebo Comparator group

Description:

Sonar guided stellate ganglion injection of 8 ml of sterile saline 0.9% using high frequency probe as a placebo. Stellate ganglion is identified at the level of C6 just under the pulsation of the ipsilateral carotid artery

Treatment:

Procedure: sonar guided stellate ganglion injection

Stellate ganglion

Active Comparator group

Description:

Sonar guided stellate ganglion injection of 8ml bupivacaine 0.25% using high frequency probe. . Stellate ganglion is identified at the level of C6 just under the pulsation of the ipsilateral carotid artery

Treatment:

Procedure: sonar guided stellate ganglion block