Role of Metabolomics in the Diagnosis of Endometriosis

University of Cagliari

Status: Completed

Conditions: Endometriosis

Treatments: Procedure: laparoscopic surgery, obtainment of biological samples

Study type: Observational

Funder types: Other

Identifiers

NCT02337816

ENDOMETAB01

Details and patient eligibility

About

Endometriosis is one of the most common benign gynecological, affecting about 10% of premenopausal women. The pathophysiology of this disease is still not completely clear. Despite its prevalence, there is no blood test available for the diagnosis of endometriosis and the average delay time to diagnosis is 9.4 years.

Metabolomics is a scientific discipline that studies changes in metabolites related to the pathophysiology of the disease.

Aim of the study is to identify an alteration in the expression of the metabolites in women with endometriosis

Enrollment: 54 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women of childbearing age ;
• written consent to laparoscopic surgery;
• written consent to the study .

Exclusion criteria

• Suspicion or diagnosis of malignant disease
• Inability or unwillingness to provide written consent

Trial design

54 participants in 2 patient groups

Endometriosis

Description:

Patients will undergo laparoscopic surgery in order to treat endometriosis. Biopsies will be performed for histological confirmation of the disease. Samples of urine and blood, with the purpose to study metabolitis, will be collected before surgery.

Treatment:

Procedure: laparoscopic surgery, obtainment of biological samples

Controls

Description:

Patients will undergo laparoscopic surgery in order to treat benign gynecological diseases. Biopsies will be performed for histological confirmation of the disease. Samples of urine and blood,with the purpose to study metabolitis, will be collected before surgery.

Treatment:

Procedure: laparoscopic surgery, obtainment of biological samples