Role of Methylene Blue in Parotid Surgery

Assiut University

Status: Unknown

Conditions: Parotid Tumor

Treatments: Procedure: Methylene blue dye

Study type: Interventional

Funder types: Other

Identifiers

NCT05401370

MB in parotid surgery

Details and patient eligibility

About

usefulness of the methylene blue staining for identification of facial nerve in parotid gland surgery

Full description

The specific surgical morbidity remains significant in parotid gland surgery. In addition to temporary facial weakness and permanent facial nerve injury, postparotidectomy depression and Frey's syndrome (gustatory sweating) are specific for this type of surgery. To reduce the surgical morbidity, several modifications of parotidectomy have been implemented but postsurgical complications remain especially facial nerve injury . To overcome this difficulty, an identification method might be used such as preoperative intravital staining of the gland with methylene blue (MB).

Although MB staining is not designed to be used as a sole technique, it can be combined with other techniques such as identification of the anatomic landmarks. MB staining is simple, inexpensive, and not time consuming technique.It is an indirect facial nerve identification technique, because there is no nerve handling,thus decreasing iatrogenic nerve impairment.After injection of the parotid gland with MB dye, fine white nerve fibers can be observed . Tumors in the parotid gland are also easily seen because they are not stained and will be visible in the surgical field.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All new cases presented with primary benign or malignant parotid tumors.

Exclusion criteria

• Cases with secondary tumors of the gland

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

20 participants in 2 patient groups

MB group

Active Comparator group

Description:

Mb group will undergo surgeries with methylene blue staining

Treatment:

Procedure: Methylene blue dye

Control group

No Intervention group

Description:

Control group will undergo surgeries without methylene blue staining