Role of Multi-modality Imaging in the Assessment of Chemotherapy Related Cardiac Dysfunction Among Cancer Patients

Assiut University

Status

Not yet enrolling

Conditions

2D Speckle Tracking Echocardiography

Breast Cancer

Cardiac Magnetic Resonance

Treatments

Device: Two dimensions speckle tracking and three dimension echocardiography and cardiac magnetic resonance imaging

Study type

Observational

Funder types

Other

Identifiers

NCT06206395

Cardiotoxicity and cancer

Details and patient eligibility

About

The field of oncology has advanced remarkably. Some of the old and new emerging cancer therapies are associated with development of cardiovascular toxicities , which may have the potential to offset the gains in survival obtained with this cancer treatment advances. Much of the focus on cardiovascular toxicities has been in the early detection of myocardial damage and prediction of cancer therapeutics-related cardiac dysfunction (CTRCD). The main strategy for these patients is timely diagnosis and treatment of high-risk individual Cardiac dysfunction associated with cancer treatment is the main cause of mortality in cancer survivors. The mortality rate is recorded to be up to 60% in the first two years after therapy. The most commonly associated drugs with cardiotoxicity are anthracycline (AC) and monoclonal antibodies (such as trastuzumab). Other new agents, such as vascular endothelial growth factor (VEGF) inhibitors, immunotherapies, and proteasome inhibitors, can also cause cardiac dysfunction .

Enrollment

190 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Cancer patients ≥ 18 years of age, and scheduled to receive chemotherapy will be included.

Exclusion criteria

Contraindications to CMR (e.g.: patients with pacemakers, defibrillators or other implanted electronic devices).
Life expectancy ≤ 12 months.
Participating in another oncology clinical trial;
Prior exposure to chemotherapy;
History of active or prior cardiac disease (e.g., myocardial infarction, heart failure or base line left ventricular ejection fraction less than 55%).