Role of Neuronal Guidance Proteins as Diagnostic Markers for Acute Kidney Injury (AKI) (NEUKID)

University Hospital Tuebingen

Status: Not yet enrolling

Conditions: Acute Kidney Injury

Study type: Observational

Funder types: Other

Identifiers

NCT05924269

NEUKID

Details and patient eligibility

About

Acute kidney failure remains one of the most challenging entities to diagnose in clinical medicine, especially in the field of intensive care. The diagnosis of acute kidney injury is based solely on urine output and serum creatinine, both of which could also be influenced by other factors. A more sensitive and faster diagnostic option would not only be desirable but of utmost clinical importance. Therefore, the investigators aim to identify Neuronal Guidance Proteins (NGPs) as potential biomarkers for the identification and early detection of AKI with this investigation. This investigation aims to identify the possibility of diagnosing acute kidney injury, the subsequent validation of a potential biomarker will then have to take place in a multicenter study approach: Data in preclinical mouse models suggest that SEMA7A as one of the NGPs could be valuable as a biomarker, the study now aims to attempt a preliminary survey in humans and measure various NGPs.

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing cardiac surgery
• written consent

Exclusion criteria

• no written consent possible
• Polytrauma, severe burns
• Immunosuppression
• Pregnancy
• Diagnosis of Hepatitis B, Hepatitis C, and/or HIV
• Sepsis
• Pre-existing kidney damage

Trial design

600 participants in 1 patient group

Cardiac Surgery

Description:

Patients undergoing cardiac surgery