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Role of Oral Care in Prevention of Nosocomial Pneumonia Among COPD Patients

A

Assiut University

Status

Enrolling

Conditions

Nosocomial Pneumonia
COPD Exacerbation

Treatments

Other: Oral care

Study type

Interventional

Funder types

Other

Identifiers

NCT06691399
SOD2024

Details and patient eligibility

About

Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia.

Full description

Infection is a common problem and a major cause of morbidity and mortality for patients in intensive care units (ICUs). Pneumonia is the most common site of infection according to an international study of the prevalence and outcomes of infection in ICUs, which included 13,796 patients. Nosocomial pneumonia (NP) is among the leading causes of mortality in patients in the ICU. Notably, the incidence of nosocomial pneumonia is increasing, and the number of infection-related deaths that follow is also increasing. Thus, preventing nosocomial pneumonia is a cost reducing and life-saving health care practice, especial in ICUs.

Nosocomial pneumonia (NP) was defined as an infection of the lower respiratory tract that does not exist at the time of admission and does not have an incubation period of infection but occurs 48 hours after admission. The most important cause for the development of nosocomial pneumonia is the oral environment. The oral cavity of ICU patients is an important reservoir for bacteria and provides a habitat for microorganisms that can lead to nosocomial pneumonia. Patients in ICUs acquire pneumonia by aspirating oral bacteria that have been colonized in the oral cavity into the lower respiratory tract. Due to advanced age, limited mobility, illness, and cognitive dysfunction, patients in ICUs often have difficulty maintaining oral hygiene by themselves.

Poor dental hygiene has been linked to respiratory pathogen colonization in ICU patients. Therefore, respiratory pathogens tend to colonize dental plaque and oral mucosa in these populations. Therefore, strategies to eliminate respiratory pathogens from the oral cavity may improve oral hygiene and decrease the development of nosocomial pneumonia. The aim of the present study is to assess value of preventive strategy using chlorhexidine for oral care among non-intubated COPD patients admitted to ICU upon incidence of nosocomial pneumonia.

Enrollment

60 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients diagnosed as COPD
  • admitted to ICU with acute exacerbation
  • need for noninvasive ventilatory support including noninvasive ventilation anf high flow nasal cannula

Exclusion criteria

  • patients refusing to participate
  • End stage organ failure (Heart Failure, Liver cell failure and/or Renal failure

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

60 participants in 2 patient groups, including a placebo group

Routine oral care (Group 1)
Placebo Comparator group
Description:
Group (1) will receive routine oral care twice daily with gauze for cleansing and tooth brushing
Treatment:
Other: Oral care
Chlorhexidine oral care
Active Comparator group
Description:
Group (1) will receive routine oral care twice daily with gauze for cleansing and tooth brushing plus oral care with chlorohexidine solution (concentration 1.2%)
Treatment:
Other: Oral care

Trial contacts and locations

1

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Central trial contact

Maiada MD Kamaleldin Hashem, Ass. Prof.; Waleed MD Gamal Elddin Khaleel, Ass. Prof.

Data sourced from clinicaltrials.gov

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