Role of Oral Steroids in Reducing Recurrence of Urethral Stricture After Direct Vision Internal Urethrotomy

Services Hospital, Lahore

Status: Completed

Conditions: Recurrence

Treatments: Drug: No steroid; Drug: Steroid Drug

Study type: Interventional

Funder types: Other

Identifiers

NCT05069883

AF1

Details and patient eligibility

About

It was a randomized controlled trial conducted at department of Urology, Armed Forces Institute of Urology, Rawalpindi from 1st January, 2018 July 2019 to 31st March 2021 to determine the role of oral steroids after Direct Vision Internal Urethrotomy to reduce the recurrence rate of urethral strictures.

Enrollment: 180 patients

Sex: Male

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with urethral stricture with restricted urine flow of < 15 ml/min on uroflowmetry

Exclusion criteria

• Patients presenting with post-anastomotic urethroplasty strictures (assessed on history and medical record),
• Patients with post-TURP strictures
• Patients with neurogenic bladder
• Patients with prior history of steroid use
• Patients with extravasation during optical internal urethrotomy

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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180 participants in 2 patient groups, including a placebo group

Oral Steroid

Experimental group

Description:

In this group oral steroids were given after Direct vision internal urethrotomy

Treatment:

Drug: Steroid Drug

No Oral Steroids

Placebo Comparator group

Description:

In this group no oral steroids were given after Direct vision internal urethrotomy

Treatment:

Drug: No steroid