Role of Oxygen for Vascular Dysfunction

Klinik für Kardiologie, Pneumologie und Angiologie

Status: Completed

Conditions: Oxygen Saturation; IMT; Endothelial Dysfunction; Forced Expiratory Volume After 1 Second; FMD; Microcirculation; Oxygen Pressure; Carbon Dioxide Pressure

Study type: Observational

Funder types: Other

Identifiers

NCT02127333

COPD_pO2

Details and patient eligibility

About

Hypoxemia may contribute increased morbidity and mortality in chronic obstructive pulmonary disease (COPD) patients. We aim to characterize the role of acute and chronic hypoxemia for vascular function. For this purpose we measure capillary oxygen concentration and vascular.

Vascular function is assessed by flow-mediated dilation oft he brachial artery, forearm blood flow and laser doppler perfusion imaging.

We hypothesize that hypoxemia leads to impaired vascular function.

Enrollment: 38 patients

Sex: Male

Ages: 40 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• stable coronary artery disease
• stable chronic obstructive pulmonary disease

Exclusion criteria

• acute myocardial infarction within 30 days
• acute exacerbated COPD within 30 days
• acute infections
• severe acute or chronic renal failure
• severe heart failure
• atrial fibrillation
• severe cardiac arrhythmia
• hypotension
• active malignant disease
• active rheumatic disease
• pulmonary hypertension with vasoactive therapy

Trial design

38 participants in 3 patient groups

CAD patients with COPD

CAD patients without COPD

healthy volunteers