Role of Pancreatic Triglyceride Content in Beta-cell Function

The University of Texas System (UT)

Status: Completed

Conditions: Obesity; Type 2 Diabetes

Treatments: Other: No intervention planned.

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00602953

1K23RR02447001

042007-021

Details and patient eligibility

About

The study evaluates if fat accumulates in the pancreas in individuals at risk of developing obesity-related diabetes. It also evaluates if the amount of fat in the pancreas can predict the residual functional capacity of the pancreas (insulin secretion).

Enrollment: 101 patients

Sex: All

Ages: 21 to 99 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• adults without prior history of pancreatic disease (other than diabetes)

Exclusion criteria

• use of unapproved medications
• contraindications to the MRI procedure
• contraindications to frequent blood draws
• pregnancy
• use of more than 2 alcoholic drinks/day

Trial design

101 participants in 5 patient groups

Healthy volunteers

Description:

Normal weight and normal glucose tolerance.

Treatment:

Other: No intervention planned.

Pre-diabetes

Description:

Impaired fasting glucose of impaired glucose tolerance.

Treatment:

Other: No intervention planned.

Overweight

Description:

Overweight or obese volunteers, but with normal fasting and postprandial glucose levels.

Treatment:

Other: No intervention planned.

Type 2 diabetes

Description:

Patients with type 2 diabetes.

Treatment:

Other: No intervention planned.

Type 1 diabetes

Description:

Patients with type 1 diabetes.

Treatment:

Other: No intervention planned.