Role of Patient Selection for Pancreatic Resections (PatSelPanc)

Medizinische Hochschule Brandenburg Theodor Fontane

Status: Completed

Conditions: Pancreas Disease

Treatments: Other: Persons with pancreatic resection in a hospital with at least 50 pancreatic resections annually (observational),; Other: Persons with pancreatic resection in a hospital not performing at least 50 pancreatic resections annually (observational),

Study type: Observational

Funder types: Other

Identifiers

NCT06390891

PatSelPanc

Details and patient eligibility

About

Pancreatic surgery is complicated and risky, especially for pancreatic cancer. It's been noticed that having these surgeries done at specialized centers can lead to better outcomes and survival rates. However, factors like patient selection and hospital conditions also play an important role. Some studies show that more surgeries done at a hospital might not always mean better results, as the type of patients and procedures can vary. To understand this better, the present study compared outcomes and patient characteristics between high-volume pancreatic centers and others.

Full description

The study utilized German nationwide administrative data (diagnosis-related group statistics) spanning from 2010 to 2018. Persons who underwent pancreatic resections during this period were included, with exclusions for certain criteria like underage and type of procedure. Various factors including patient demographics, diagnoses, procedures, and comorbidities were analyzed to assess in-hospital mortality rates. High-volume pancreatic centers (HVPCs) were identified as those performing at least 50 procedures annually. Statistical analyses included comparing crude and adjusted mortality rates and assessing patient characteristics between HVPCs and non-HVPCs. Models were adjusted for multiple variables, and methods like the Cochran-Armitage trend test and mixed models were employed. Additionally, the study investigated how differences in patient characteristics between HVPCs and non-HVPCs affected mortality rates.

Enrollment: 86,073 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• partial or total pancreatic resections between 2010 and 2018

Exclusion criteria

• childhood (<18 years)
• subjects with a pancreatic transplantation procedure
• missing information on age or gender

Trial design

86,073 participants in 2 patient groups

Patients treated in high-volume pancreatic centers

Description:

Patients treated at a hospital performing at least 50 pancreatic resection procedures annually during 2010 to 2018

Treatment:

Other: Persons with pancreatic resection in a hospital with at least 50 pancreatic resections annually (observational),

Patients treated in low-volume pancreatic centers

Description:

Patients not treated at a hospital performing at least 50 pancreatic resection procedures annually during 2010 to 2018

Treatment:

Other: Persons with pancreatic resection in a hospital not performing at least 50 pancreatic resections annually (observational),