Role of Percutaneous Vertebroplasty in Treatment of Vertebral Tumors (PVP)

Assiut University

Status: Unknown

Conditions: Bone Tumor

Treatments: Drug: Bone Cements

Study type: Observational

Funder types: Other

Identifiers

NCT03427632

PVPfortumors

Details and patient eligibility

About

Percutaneous vertebroplasty is a new technique to strengthen bone and reduce pain for patients with vertebral tumors

Full description

Destructive vertebral lesions are a common in metastatic disease, multiple myeloma and lymphoma. Symptoms are caused by pathologic fracture consequences secondary to vertebral destruction, development of spinal instability and compression of adjacent neurological elements. Nonoperative treatments include radiotherapy, hormone therapy, cytotoxic drugs which are effective to halt the osteolytic process and reverse the neurological compromise, however; they cannot provide stability or relieve pain or cord compression. Surgical management options including vertebrectomy, reconstruction with a cage or PMMA bone cement, and stabilization with pedicle screws can restore spinal canal support and neurological functions also control pain, however; usually associated with high postoperative morbidity and mortality. Also not advisable for multifocal spinal disease. Percutaneous vertebroplasty is a new technique to strengthen bone and reduce pain. It is percutaneous, minimally invasive, image-guided procedure that involves injection of radio-opaque bone cement into a partially collapsed vertebral body, in an effort to provide stability and pain relief. The exact mechanism of pain relief remains unclear. Proposed theories include more favourable biomechanics after cement strengthening, chemical toxicity and exothermic effect of cement polymerization on nerve endings.

Enrollment: 11 estimated patients

Sex: All

Ages: 1 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Spinal instability
• Pain with movement
• Multiple level involvement
• Expected survival 3-6 months

Exclusion criteria

• Absolute
• Asymptomatic
• improving on medical treatment without worsening of the collapse.
• infection local or systemic
• uncorrectable coagulopathy
• Allergy to bone cement or contrast media
• Relative
• Radicular pain
• Tumor extension inside the vertebral canal or cord compression
• Fracture of the posterior column
• Sclerotic metastasis
• Diffuse metastases

Trial design

11 participants in 1 patient group

percutaneous Vertebroplasty

Description:

patients meet the inclusion and exclusion criteria will be subjected to percutaneous vertebroplasty receiving bone cement (Polymethyl methacrylate)

Treatment:

Drug: Bone Cements