Role of Peripheral Vision in Scene Perception (PERISCE)

Grenoble Alpes University Hospital Center (CHU) logo

Grenoble Alpes University Hospital Center (CHU)

Status

Not yet enrolling

Conditions

Primary Open-angle Glaucoma (POAG)

Treatments

Behavioral: Psychophysical evaluation

Study type

Observational

Funder types

Other

Identifiers

NCT05539508
2021-A01986-35

Details and patient eligibility

About

Despite its low spatial resolution, peripheral vision is very useful for rapidly categorizing a visual scene. Low spatial frequencies of a visual stimulus available in peripheral vision would allow a coarse categorization of the scene and objects (deciding, for example, whether it is an urban or natural landscape). This first representation would then trigger predictive mechanisms which would subsequently guide a more detailed visual analysis in central vision. The psychophysical studies that the investigators have already conducted in this scientific context has been carried out under normal vision conditions. The objective of this project is to study the influence of peripheral vision on central vision with an original approach: What are the consequences of a loss of peripheral vision on the processing performed in central vision? The project will concern patients with glaucoma. This ophthalmic pathology particularly affects the peripheral retina and thus represents a good pathological cognitive model of a visual recognition system in which peripheral vision is less important. The investigators will conduct psychophysical studies with glaucomatous patients and healthy volunteers with normal vision. All participants will be required to perform a short experiment on a computer (15 minutes) where they will look at different photographs of scenes of different luminance and spatial frequencies. Participants will have to perform various tasks on these images using the keys on the keyboard.

Enrollment

120 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For patients :

  • between 18 and 80 years old
  • stable bilateral primary open angle glaucoma (POAG)
  • visual acuity > 5/10 for distant vision for the eye tested
  • peripheral visual field defect on the eye tested measured through a Humphrey Visual Field Analyzer

For healthy volunteers :

  • between 18 and 80 years old
  • visual acuity > 5/10
  • absence of ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)

Exclusion criteria

  • ophthalmologic disease other than Glaucoma (age-related macular degeneration, cataract except for uncomplicated cataract surgery, amblyopia, optic neuropathy, diabetic retinopathy …)
  • treated with medication that might compromise sustained attention (benzodiazepine, narcoleptics)

Trial design

120 participants in 2 patient groups

Primary open-angle glaucoma (POAG) group
Treatment:
Behavioral: Psychophysical evaluation
Age-matched normally sighted control group
Treatment:
Behavioral: Psychophysical evaluation

Trial contacts and locations

0

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Central trial contact

Carole Peyrin, PhD

Data sourced from clinicaltrials.gov

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