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This is a transversal double-centre study. Patients will be recruited from outpatient consultations. They will have buccal inflammation caused by periodontal disease (frequent oral infections, mostly with GRAM (-) bacteria). Three groups of 80 patients, corresponding to slight, moderate and severe periodontal disease, will be formed according to the results of radiological and clinical examinations.
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Inclusion criteria
Pre-Inclusion criteria:
DEFINITIVE INCLUSION CRITERIA
Exclusion criteria
Persons not covered by the national health insurance agency
Patients with a high risk of infectious endocarditis who require prophylaxis for any medical act involving blood
Patients who have taken at least once during the 8 days preceding the definitive inclusion an anti-inflammatory dose of NSAIDS and/or a salicylate (blood sample)
Patients who have had long-term treatment (>6 months) with corticoids at a dose of at least 15 mg per day
Patients on antibiotics less than 15 days before the blood sample
Patients with oral inflammation requiring treatment with antibiotics or anti-inflammatory drugs during the pre-inclusion
Scaling during the 24 hours before the blood sample
History of oral cancer or cancer of the pharynx
Active cancer (patient undergoing treatment or diagnosis within the previous 5 years)
Iatrogenic, spontaneous or therapeutic immunodepression (patient on immunosuppressants or antiretrovirals),
Systemic or organ specific inflammatory syndrome not related to the periodontal disease
Pregnancy
Impossibility to cooperate due to a psychiatric disease, dementia
Patients unable to understand the protocol
242 participants in 3 patient groups
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Data sourced from clinicaltrials.gov
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