Role of Preoperative Tapentadol in Reduction of Perioperative Analgesic Requirement After Breast Conservative Surgery in Cancer Patients.

Shaukat Khanum Memorial Cancer Hospital & Research Centre

Status: Completed

Conditions: Breast Cancer

Treatments: Drug: Tapentadol; Other: Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT07320781

IRB-23-20

Details and patient eligibility

About

This study evaluated the preemptive analgesic efficacy of Tapentadol in reducing peri operative analgesic requirements among patients undergoing breast cancer surgery.

Full description

A double blinded prospective RCT was conducted with 70 patients undergoing breast cancer surgery with 35 patients being studied with Administrated drug & other 35 as placebo. Intraoperative & postoperative morphine consumption was calculated and documented.

Enrollment: 70 patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 18-60 years
2. ASA 1,2,3
3. Patients scheduled for breast conservation surgery -

Exclusion criteria

1. Patient refusal
2. CKD greater than 3
3. BMI greater than 35
4. Known drug allergy -

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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70 participants in 2 patient groups, including a placebo group

Tapentadol

Active Comparator group

Description:

Control drug (Tapentadol )

Treatment:

Drug: Tapentadol

Placebo

Placebo Comparator group

Description:

Placebo sodium bicarbonate/ peppermint oil tablet

Treatment:

Other: Placebo