Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

T

The Third Central Clinical College of Tianjin Medical University

Status and phase

Completed
Phase 4

Conditions

Cerebral Arterial Aneurysm

Treatments

Drug: sevoflurane
Drug: propofol postconditioning

Study type

Interventional

Funder types

Other

Identifiers

NCT02691416
ThirdCCCTianjin

Details and patient eligibility

About

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.

Full description

intracranial aneurysm surgery may lead to regional ischemic reperfusion injury. Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats. As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy

Enrollment

60 patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Clinical diagnosis intracranial aneurysm surgery ,
  • American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ.

Exclusion criteria

  • severe hepatic and renal dysfunction
  • coagulation disorder
  • taking antioxidant perioperative period

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

propofol postconditioning
Experimental group
Description:
1.2mg/L propofol
Treatment:
Drug: propofol postconditioning
Drug: sevoflurane
sevoflurane
Experimental group
Description:
0.5%-2% sevoflurane
Treatment:
Drug: sevoflurane

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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