Role of Propofol Postconditioning on Oxidative Stress and Cognitive Function

The Third Central Clinical College of Tianjin Medical University

Status and phase: Completed; Phase 4

Conditions: Cerebral Arterial Aneurysm

Treatments: Drug: sevoflurane; Drug: propofol postconditioning

Study type: Interventional

Funder types: Other

Identifiers

NCT02691416

ThirdCCCTianjin

Details and patient eligibility

About

The purpose of this study was to evaluate differences between propofol postconditioning and sevoflurane anesthesia in the intracranial aneurysm surgery about antioxidant effect.

Full description

intracranial aneurysm surgery may lead to regional ischemic reperfusion injury. Propofol, as an antioxidative phenol, has been demonstrated that mitigate the brain I/R in rats.

As for sevoflurane, some investigation indicated that sevoflurane is able to reduce oxidative stress in cell(except neuronal cell lines ) and rodent models, but the antioxidant effect did not found in human minor incision surgeries, furthermore, oxidative stress was raised in the major surgeries including orthopedic surgeries, hysterectomy, cholecystectomy, and thoracotomy

Enrollment: 60 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis intracranial aneurysm surgery ,
• American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ.

Exclusion criteria

• severe hepatic and renal dysfunction
• coagulation disorder
• taking antioxidant perioperative period

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

propofol postconditioning

Experimental group

Description:

1.2mg/L propofol

Treatment:

Drug: propofol postconditioning

Drug: sevoflurane

sevoflurane

Experimental group

Description:

0.5%-2% sevoflurane

Treatment:

Drug: sevoflurane