Role of Proteomics and Metallomics in Cerebral Vasospasm Following Subarachnoid Hemorrhage

State University of New York - Upstate Medical University

Status: Completed

Conditions: Hydrocephalus; Subarachnoid Hemorrhage; Cerebral Vasospasm

Study type: Observational

Funder types: Other

Identifiers

NCT01799018

IRB#225490

Details and patient eligibility

About

The purpose of this study is to determine the role of Proteomics and Metallomics in Cerebral Vasospasm following Subarachnoid Hemorrhage

Enrollment: 40 patients

Sex: All

Ages: 18 to 89 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non traumatic SAH documented by CT scan
• Patient with SAH who would need external ventricular drain (EVD) for the management of hydrocephalus
• Patients with normal pressure Hydrocephalus that require an external drain
• Control (non - hemorrhagic) group - CSF collected from patients with posterior fossa tumor or stroke with EVD in place for the management of hydrocephalus.

Exclusion criteria

• Recent infection within last 1 month of presentation- can increase inflammatory markers
• Recent surgery or acute myocardial infarction within last 1 month of presentation
• Age > 89 years or < 18 years

Trial design

40 participants in 2 patient groups

SAH Patients

Description:

Patients admitted with the diagnosis of aneurismal subarachnoid hemorrhage (SAH) and cerebral angiogram negative SAH who would need to have the external ventricular drain (EVD) placed for the management of hydrocephalus.

Control Patients

Description:

Patients with non-hemorrhagic brain pathology such as posterior fossa tumor or stroke who will have the CSF sampling for diagnostic or therapeutic purposes.