Role of Regulatory T Cells in Pathogenesis of Primary IgA Nephropathy

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Glomerulonephritis, IGA

Treatments: Procedure: gene transcription and cytometry

Study type: Interventional

Funder types: Other

Identifiers

NCT00521508

2007-A00129-44

0608118

DGS 2007-0184

Details and patient eligibility

About

Along structural IgA abnormalities, hyperproduction of IgA is thought to play a role in the pathogenesis of primary IgA nephropathy. CD4+CD25+Fox3P regulatory T cells are instrumental in suppressing adaptative immune responses, including B cells production of immunoglobulins. We, the researchers at Centre Hospitalier Universitaire de Saine Etienne, will test the hypothesis that IgA production in patients with IgA nephropathy is dysregulated because of a quantitative and/or qualitative defect of CD4+CD25+FoxP3+ regulatory T cells.

Enrollment: 45 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with pathogenesis of Berger's disease confirmed by renal biopsy
• Glomerular filtration > 60 ml/min/1,73m2
• Written informed consent
• Patient affiliated to social insurance

Exclusion criteria

• Immunosuppressor treatment within 6 months before the study inclusion
• Clinical infection within 2 months before the study inclusion
• C-reactive protein (CRP) > 10 mgL-1

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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45 participants in 3 patient groups

1

Other group

Description:

Patient affected by Berger's disease confirmed by renal biopsy with increased rate of Ig A

Treatment:

Procedure: gene transcription and cytometry

2

Other group

Description:

Patient affected by Berger's disease with normal rate of Ig A

Treatment:

Procedure: gene transcription and cytometry

3

Other group

Description:

Healthy volunteers

Treatment:

Procedure: gene transcription and cytometry