Role of Residual Urine and Asymptomatic Prostatitis in the Development of Urinary Tract Infections in Spinal Cord Injury

Swiss Paraplegic Research, Nottwil

Status: Completed

Conditions: Urinary Tract Infection

Treatments: Other: sonographic assessment of residual urine, urine culture

Study type: Observational

Funder types: NETWORK

Identifiers

NCT01601041

2011-16

Details and patient eligibility

About

The purpose of this prospective study is to investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract infections in patients suffering from chronic (> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization.

The following hypotheses will be tested:

1. The amount of residual urine after intermittent catheterization is significantly greater in SCI patients suffering from frequent (>2 /year) urinary tract infections compared to those without.
2. The incidence of asymptomatic bacterial prostate infections is significantly higher in SCI patients suffering from frequent (>2 /year) urinary tract infections compared to those without.

Full description

To investigate the association between the amount of residual urine and asymptomatic bacterial prostate infection with the occurrence of recurrent (>2 /year) symptomatic urinary tract infections in patients suffering from chronic (> 1 year) spinal cord injury (SCI) and neurogenic lower urinary tract dysfunction performing intermittent catheterization, patients perform self-catheterization twice (before and after urodynamic testing. After each catheterization, residual urine is assessed by ultrasound. Prior to urodynamic testing, prostate massage is performed, bacterial cultures of the fluid and the urine are initiated and the results of these cultures will be analysed .

Enrollment: 60 patients

Sex: Male

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• male patients with chronic (> 1 year) spinal cord injury
• bladder management by intermittent catheterization

Exclusion criteria

• symptomatic urinary tract infection
• prostate pathology
• immunodeficiency
• antibiotic therapy
• missing informed consent

Trial design

60 participants in 2 patient groups

urinary tract infection

Description:

urinary tract infection in male patients with neurogenic bladder dysfunction due to spinal cord injury managed by intermittent catheterization

Treatment:

Other: sonographic assessment of residual urine, urine culture

control group

Description:

less than three urinary tract infections / year

Treatment:

Other: sonographic assessment of residual urine, urine culture